References:
- Liu Q, Bee MS, Schonbrunn A. (2009) Site specificity of agonist and second messenger-activated kinases for somatostatin receptor subtype 2A (Sst2A) phosphorylation.
- Liu Q, Dewi DA, Liu WS, Bee MS, Schonbrunn A. (2008) Distinct phosphorylation sites in the sst2 somatostatin receptor control internalization, desensitization, and arrestin binding. Mol Pharmacol 73(2): 292-304
- Cescato R, Schulz S, Waser B, Eltschinger V, Rivier JE, Wester HJ, Culler M, Ginj M, Liu Q, Schonbrunn A, Reubi JC. (2006) Internalization of sst2, sst3 and sst5 receptors: Effects of somatostatin agonists and antagonists. J Nucl Med 47 (3): 502-511
- Liu Q, Cescato R, Dewi DA, Rivier J, Reubi JC, Schonbrunn A. (2005) Receptor signaling and endocytosis are differentially regulated by somatostatin analogs. Mol Pharmacol 68 (1): 90-101.
- Liu Q, Reubi JC, Wang Y, Knoll BJ, Schonbrunn A. (2003) In vivo phosphorylation of the somatostatin 2A receptor in human tumors. J Clin Endocrinol Metab 88 (12): 6073-6079.
- Liu Q, Schonbrunn A. (2001) Agonist-induced phosphorylation of somatostatin receptor subtype 1 (sst1): relationship to desensitization and internalization. J Biol Chem 276(5): 3709-17.
Qisheng Liu, M.D, Ph.D.
Instructor
UTHSC, Medical School, (713) 500-7471
Qisheng.Liu@uth.tmc.edu
Somatostatin receptor regulation
I work with Dr. Schonbrunn to explore the function and regulation of somatostatin receptors. My research interest is focused on agonist or second messenger activation-induced phosphorylation of somatostatin receptors and the role of receptor phosphorylation in receptor internalization and desensitization.
My study showed that the events of somatostatin receptor 2A (sst2A) internalization and desensitization are differentially regulated by regional receptor phosphorylation. Through testing a serial of phosphorylation deficit mutant receptors, I have identified the specific receptor sites responsible for rapid receptor internalization.
My current project is to identify the specific sites responsible for protein kinase C (PKC) and the G protein coupled receptor kinase (GRK) mediated sst2A receptor phosphorylations, and to investigate the effect of GRK subtypes on receptor site-specific phosphorylation and internalization.
