References:
- Streckfus, C.F., Mayorga-Wark, O., Arreola, D., Edwards, C., Bigler, L., and W.P. Dubinsky. Breast cancer related proteins are present in saliva and are modulated secondary to carcinoma in situ of the breast. Cancer Inv, in press.
- Hergenroeder, G., Redell, J.B., Moore, A.N., Dubinsky, W.P., Funk, R.T., Crommett, J., Clifton, G.L., Levine, R., Valadka, A., and Dash, P.K. Identification of serum biomarkers in brain injured adults: potential for predicting elevated intracranial pressure. J. Neurotrauma in press
- Streckfus C.F., Dubinsky W.P. Proteomic analysis of saliva for cancer diagnosis. Expert Rev Proteomics. 2007 4(3):329-32
- Streckfus, C., Bigler, L., Dubinsky, W. and J. Bull. Salivary Biomarkers for the Detection of Cancer. In: Progress in Tumor Marker Research. Ed. Lee I. Swenson. Chapter III, Nova Sciences Publishers, Inc, 2007
- Fant M, Barerra-Saldana H, Dubinsky W, Poindexter B, Bick R. The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast. Mol Reprod Dev. 2007 Jul;74(7):922-9.
- Patel LS, Mitchell CK, Dubinsky WP, O'Brien J. Regulation of gap junction coupling through the neuronal connexin Cx35 by nitric oxide and cGMP. Cell Commun Adhes. 2006 Jan-Apr;13(1-2):41-54.
- Braun MC, Li L, Ke B, Dubinsky WP, Pickering MC, Chang JY Proteomic profiling of urinary protein excretion in the factor H-deficient mouse. Am J Nephrol. 2006;26(2):127-35. Epub 2006 Mar 21.
- Yu Z, Kuncewicz T, Dubinsky WP, Kone BC. Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene. J Biol Chem. 2006 Apr 7;281(14):9101-9. Epub 2006 Feb 7.
William P. Dubinsky, Ph.D.
Director, Proteomics Core Laborartory
UTHSC, Medical School, (713) 500 - 6311
William.P.Dubinsky@uth.tmc.edu
Proteomics and Biomarker Discovery
My research is a combination of basic and translational studies using mass spectroscopic and biochemical approaches to examine and relate differential expression of proteins to disease processes. The main focus of my laboratory is on the protein composition of physiological fluids such as saliva, bronchial and alveolar secretions, plasma etc. We have found for example that salivary protein composition shows marked changes in specific protein levels in disease states compared to normal health. Two possibilities immediately arise. Can these changes tell us anything about the mechanism or pathophysiology of the disease? Equally important, can these changes in protein composition be used in the early diagnosis of the disease, permit the evaluation of the treatment of the disease, or predict the outcomes of the disease?
