- Fu J, Akhmedov D, and Berdeaux R. (2013) The short isoform of the ubiquitin ligase NEDD4L is a CREB target gene in hepatocytes. PLoS ONE, 8(10): e78522.
- Clark RI, Tan S, Péan CB, Roostalu U, Vivancos V, Bronda K, Pilátová M, Fu J, Walker DW, Berdeaux R, Geissmann F and Dionne MS. (2013) Mef2 is an in vivo immune-metabolic switch. Cell, 155(2): 435-447.
- Chatterjee S, Nam D, Guo B, Kim JM, Wennier GE, Lee J, Berdeaux R, Yechoor VK and Ma K. (2013) Brain and Muscle Arnt-like 1 is a key regulator of myogenesis. J Cell Sci, 126 (Pt 10): 2213-24.
- Stewart R*, Akhmedov D*, Robb C, Leiter C, and Berdeaux R. (2013) Regulation of SIK1 abundance and stability is critical for myogenesis. PNAS 110(1): 117-22. *, equal contribution.
- Luo J, Stewart R, Berdeaux R and Hu H. (2012) Tonic inhibition of TRPV3 by Mg2+ in mouse epidermal keratinocytes. J Invest Dermatol 132(9): 2158-65.
- Berdeaux R and Stewart R. (2012) cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration.Am J Physiol Endocrinol Metab 303(1): E1-E17.
- Stewart R, Flechner L, Montminy M, Berdeaux R. (2011) CREB Is Activated by Muscle Injury and Promotes Muscle Regeneration. PLoS ONE 6(9): e24714.
- Berdeaux R (2011). Metabolic regulation by SIK kinases. Front Biol 6(3): 231-241.
- Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz J, Hogan MF, Singh P, Goebel N, Miller N, Cui J, Jones MR, Taylor KD, Hsueh WA, Rotter JI and Montminy M. (2010) The CREB coactivator CRTC3 links catecholamine signaling to energy balance. Nature. 468(7326): 933-9.
- Berdeaux, R., Goebel, N., Banaszynski, L., Takemori, H., Wandless, T., Shelton, G.D., and Montminy, M. (2007) SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat. Med. 13(5): 597-603.
- Canettieri, G., Koo, S.H., Berdeaux, R., Heredia, J., Hedrick, S., Zhang, X., Montminy, M. (2005) Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab. 2(5):331-8.
- Berdeaux, R.L., Díaz, B., Kim, L., Martin, G.S. (2004) Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. J. Cell Biol. 166(3):317-23.
- Hofer, F., Berdeaux, R., Martin, G.S. (1998) Ras-independent activation of Ral by a Ca(2+)-dependent pathway. Curr. Biol. 8(14):839-42.
Rebecca Berdeaux, Ph.D.
UTHSC-H Medical School, 713-500-5653
Ph.D.: University of California, Berkeley 2003
- The Salk Institute, 2008
Signal-dependent transcription in metabolic tissues
Most mammalian tissues are highly adaptive to changing physiological states. Extracellular cues or signals not only prompt immediate adjustments within cells in seconds or minutes, but also frequently initiate longer-term responses through induction or repression of gene expression. Signal-dependent transcription is a particularly important means by which metabolically active tissues adapt to changing nutrient availability, physical demands and even acute tissue damage. Our laboratory studies one such transcriptional pathway activated by hormonal signaling through the second messenger cAMP to the transcription factor CREB. One of the genes induced by CREB in many tissues is a serine/ threonine kinase called SIK1 (salt inducible kinase 1). SIK1, in turn, either feeds back to inhibit CREB or feeds forward to promote activity of other transcription factors, such as the myocyte enhancer factor MEF2.
We hypothesize that SIK1 is temporally regulated by transcriptional and post-translational mechanisms to allow appropriate physiologic responses in liver and skeletal muscle. Moreover, we posit that dysregulated SIK1 activity could contribute to pathophysiologic states including type 2 diabetes and muscle damage after injury or during aging. Using biochemical approaches and mouse genetics, we are currently investigating regulation and function of SIK1 in both organ systems, with an aim of better defining general and tissue-selective mechanisms of SIK1 regulation in vivo.
Located within the thriving Texas Medical Center, our laboratory and department are equipped with state-of-the art instrumentation for phenotypic analysis of mice and tissues, confocal microscopy, in vivo bioluminescence reporter imaging in mice, and biochemical assays of cellular signaling. We study cell signaling in primary hepatocytes and myoblasts and develop unique transgenic mouse models to rigorously test our hypotheses.
Postdoctoral and graduate student training opportunities are available for exceptional, highly motivated candidates starting July 2011. To apply for funded postdoctoral positions, please email your CV, a brief statement of career goals and list of publications. Graduate students admitted to the Graduate School of Biomedical Sciences at the University of Texas Health Science Center Houston (http://www.uthouston.edu/gsbs/) may perform tutorial rotations and subsequently pursue coursework and a thesis project through the Cell and Regulatory Biology Program (http://ibp.med.uth.tmc.edu/crb/).