Department of Internal Medicine

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References:

  • Gorfe, A. A.; McCammon, J. A., Similar Membrane Affinity of Mono- and Di-S-acylated Ras Membrane Anchors: A New Twist in the Role of Protein Lipidation. J. Am. Chem. Soc. 2008, 130, 12624-12625.
  • Gorfe, A. A.; Baron, R.; McCammon, J. A., Water-membrane partition thermodynamics of an amphiphilic lipopeptide: An enthalpy driven hydrophobic effect Biophys J. 2008, 95, 3269-3277.
  • Gorfe, A. A.; Grant, B. J.; McCammon, J. A., Mapping the nucleotide and isoform dependent structural and dynamical features of Ras proteins Structure 2008, 16, 885-896.
  • Abankwa, D.; Hanzal-Bayer, M.; Ariotti, N.; Plowman, S. J.; Gorfe, A. A.; Parton, R. G.; McCammon, J. A.; Hancock, J. F., A novel switch region regulates H-ras membrane orientation and signal output. EMBO J 2008, 27, 727-735.
  • Gorfe, A. A.; Babakhani, A.; McCammon, J. A., Free Energy Profile of H-ras Membrane Anchor upon Membrane Insertion. Angew Chem Int Ed Engl 2007, 46, 8234-8237.
  • Gorfe, A. A.; Babakhani, A.; McCammon, J. A., H-ras protein in a bilayer: interaction and structure perturbation. J Am Chem Soc 2007, 129, 12280-12286.
  • Gorfe, A. A.; Hanzal-Bayer, M.; Abankwa, D.; Hancock, J. F.; McCammon, J. A., Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer. J Med Chem 2007, 50, 674-684.
  • Gorfe, A. A.; Pellarin, R.; Caflisch, A., Membrane localization and flexibility of a lipidated ras peptide studied by molecular dynamics simulations. J Am Chem Soc 2004, 126, 15277-15286.