References:
- Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I, Rassidakis GZ, Zhang W, Fujio Y, Kunisada K, Hamilton SR, Amin HM (2005) Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol;167:969-980.
- Lai R, Rassidakis GZ, Lin Q, Atwell C, Medeiros LJ, Amin HM (2005) Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Hum Pathol;36:939-944.
- Rassidakis GZ, Feretzaki M, Atwell C, Grammatikakis I, Lin Q, Lai R, Claret F-X, Medeiros LJ, Amin HM (2005) Inhibition of Akt increases p27 Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma. Blood;105:827-829.
- Amin HM, McDonnell TJ, Ma Y, Lin Q, Fujio Y, Kunisada K, Leventaki V, Das P, Rassidakis GZ, Cutler C, Medeiros LJ, Lai R (2004) Selective inhibition of STAT3 induces apoptosis and G 1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene;23:5426-5434.
- Amin HM, Medeiros LJ, Ma Y, Feretzaki M, Das P, Leventaki V, Rassidakis GZ, O’Conner SL, McDonnell TJ, Lai R (2003) Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. Oncogene;22:5399-5407.
Hesham Amin, M.D.
Assistant Professor
MD Anderson, (713) 794 - 1769
hamin@mdanderson.org
Signal Transduction; apoptosis; cell cycle; cytokines; molecular targets
The research in my laboratory is directed at exploring the mechanistic role of Jak/Stat signaling system, including its upstream and downstream activators, inhibitors, modulators, and effectors, in neoplastic diseases. A global aim of our studies is to identify potential therapeutic targets based on better understanding of Jak/Stat signaling and interacting molecules.
A tutorial in my laboratory will expose the student to tissue culture, flow cytometry, light and confocal microscopy, immunohistochemical and immunofluorescence staining, PCR, Western blotting, ELISA, cDNA and tissue microarrays, siRNA, and gene transfection.
